Abstract:Physics has made great progress in the 20th century as demonstrated in three important leaps regarding the understanding of microscopic structure of matter with the achievement of particle physics reaching its climax. Chinese particle physics at the cross of centuries is to face science frontiers in the world and its development strategy be carefully worked out according to the plan of the development of science and technology of our country and taking into account China’s actual conditions. We shall make the best use of BEPCII for the frontier study on precision measurement of charm physics, while selecting non-accelerator physics with characteristics, such as particle astrophysics experiment, cosmic ray observation, neutrino physics experiment, etc. We should vigorously strengthen international collaboration by doing a better job of the LHC experiment and actively arranging for the international collaboration on the large linear collider. The research center for high energy physics should also provide other disciplines with advanced means and large platforms.