Abstract:Supramolecular chemistry is the chemistry "beyond" molecules, which focuses on architecture and functionalization of molecular aggregates associated with non-covalent interactions. With intercrossing and combination with subjects such as materials science, life science, information science, nanoscience and nanotechnology, etc., supramolecular chemistry has developed to be supramolecular science, which is considered as an important headstream of new concepts and high-tech in the 21 st century. We introduced herein the hot points and basic problems of supramolecular science with the hope of providing references and suggestions for supramolecular research in China.