Abstract:Molluscan culture has become a dominant industry for the development of economy and society in China. Some inappropriate ways of aquaculture, however, have resulted in the worseness of environment, which would restrict and endanger the development of mariculture. Focusing on the sustainable development of enterprise and constructing a healthy aquaculture system of mudflat shellfish with friendly environment, the key technologies of large scale seed production, high efficient nursing and safe farming in the sea have been achieved by the systemic integration in theory and technology of shellfish culture. The healthy system of aquaculture includes healthy seed and environment as well as the health of consumer.