Abstract:It is a significant action for the Chinese Academy of Science (CAS) to cooperate with the university, the enterprise, the local authority and so on at home in order to promote the national innovation and advance the independent innovation ability. Nowadays, CAS should strengthen four aspects understanding of the domestic cooperation, namely strategic demand for technology, regional characteristic of resources arrangement, guidance of social resources, systematic characteristic of management. Based on the understanding, there are four key works and four kinds of abilities to do during the cooperation. Finally, the paper suggests CAS establish a research center of domestic cooperation, a multi- domains exchange platform, a set of system of management.