Abstract:It has been proved in many countries and regions that the competitiveness can be promoted and development leaping forward can be realized only by the industrial structure upgrading and spatial structure adjustment after continuously high-speed growth of national and regional economy . Based on the finished research of "Territorial Planning of Guangdong Province" leaded by Chinese Academy of Science and in view of the effect of the present international financial crisis produced on the Zhujiang River (Pearl River) Delta, this paper has analyzed the current situation of the development in this area, the negative effect of its traditional development mode, described the certainty of the optimized upgrading of the industrial structure and space structure, as well as the objectivity of the enterprise life cycle. Furthermore, the authors have discussed the strategic way of how to make the Zhujiang River Delta an urban area with international competitiveness.