Abstract:Chemistry has been creating an d generating a whole new world of substances by the tailoring and reorganizing of chemical bonds,and by the non-covalent interaction and assembly beyond the molecular level, which provides inexhaustible knowledges and substances for creative research and rapid development of other disciplines.Throughout the development of chemistry in recent years,The science of chemistry is walking towards to precision.In this paper,the development trend to precision of chemistry is accounted in three subjects: synthetic chemistry,single-molecular and single-atomic manipulation and self-assembly,based on the domestic and international development status of chemistry.Firstly,precise control on reaction selectivity in synthetic chemistry is reviewed with emphases on regioselectivity and stereoselectivity in transformation of chemical bonds.Secondly,the strategy of precise control on chemical reaction at the level of molecule and atom by the manipulation of single molecule or single atom is discussed.Lastly,self-assembly,a new generation method for the precise control on the preparation of ordered structures beyond molecular level is summarized and prospected.