Abstract:According to the plan of Innovation 2020, this paper analyses the strategic layout of Intellectual Property（IP）of the Chinese Academy of Science（CAS）from three aspects of brand building, management mode selection, and cultivation of specialized centers, expounds the characteristics and problem of the transfer of IP of CAS, makes use of the replay mode to compare the applicability of different mode of the management of IP from the point of view of the whole process of management. Moreover; some recommendations to further improve the ability of the IP management in international science and technology cooperation are proposed.