Abstract:The origination and development of informatization over the past seventy years and the role of computer science has played within them are discussed. The three steps that the global informatization course has experienced, i.e., digitization, networking, and intelligence, are described, and the new development environment for the future of informatization, formed by the ubiquity of computer, network, data, and software, is emphasized. It is indicated that intelligence, or smartness, has become the new high ground of the global competition on informatization, and, in the meantime, computational science, instead of computer science alone, has been the scientific and technical foundation of the new step of global informatization. Accordingly, scientists of all disciplines, no matter with respect to natural sciences or liberal arts, cannot possibly keep out of informatization. 2013 Nobel Prize Winners for Chemistry shows that computational science is a powerful tool to open a new chapter for all disciplines and the digital revolution of science is the frontier of the development which any subjects must face today.