Abstract:This article analyzes the development trend of e-Science, considers that current research and development of e-Science will enter the third stage of integration stage, and also the development trend demonstrates "Five News", i.e., big data drives research paradigm change, open science becomes the new trend by means of e-Science, mobile application drives the innovation, rapid development and upgrading of research information infrastructure performance and scale, and information technology promotes industrial innovation and collaborative innovation. This article points out the challenges of development of e-Science about cyber-infrastructure and applications. And the article also introduces the work and deployment on cyber-infrastructure and scientific big data and applications of CAS, and makes recommendations for development of e-Science in our country, including that our country should establish a national information system of research and development, implement national research information project, and build a comprehensive service platform to provide scientific and technological information resources and services to the national science and technology workers.