Abstract:The progress of brain science research requires the application of inter-discipline techniques, and in turn promotes the development of the latter. In the highly competitive international Brain Research Project, the first priority is to develop new techniques. This review focuses on why and how we are going to tackle several crucial techniques, including measurement of neural signals, optic imaging of neural signals and structures, combination of tans-synaptic tracing and optogenetics, and large-scale re-construction of neural circuits. Through the state-of-the-art design of national brain research-relevant major projects, we can integrate national research efforts and make a breakthrough in this field in the coming future.