Abstract:The Belt and Road Initiative is a long-term overall strategy of China's all round opening-up. The regional coordination strategy among the four regions (the East, the Middle, the Northeast, and the West) has been China's general regional development strategy since the beginning the 11th Five-Year Plan in 2006. In the 13th Five-Year Plan (2016-2020), the Belt and Road Initiative, the Yangtze River Economic Zone, and the coordinated development of Beijing-Tianjin-Hebei are determined to be the guide for expanding new space of regional development. We argue that the "Belt and Road Initiative" is China's top-level national strategy with the global vision rather than China's regional development strategy. Besides, this paper systematically analyzed and discussed the relationships and interactions between the "Belt and Road Initiative" and the overall regional coordination strategy of China, the coordinated development of Beijing-Tianjin-Hebei, and the Yangtze River Economic Zone, respectively. It requires new thinking of China's regional development strategies, which should join China's domestic regional development with international regions, put the Pearl River Delta region the same important position as that of the Yangtze River Delta region and Beijing-Tianjin-Hebei urban agglomeration in China's regional development strategy, and refine China's regional development strategy in geographical scale under the framework of the "Belt and Road Initiative" by combining administrative regions with different types of problem areas.