Abstract:Biosensors are the devices made of biological elements and physical or chemical transducers for fast and specific determination of biological or related substances, of which is a typical convergence technology. Biosensors have broad application prospects in life science research, disease diagnosis and control, bioengineering process control, agriculture and food security, environmental quality monitoring, biosafety and biosecurity, etc. 50 years after its birth, biosensor technology has entered a new phase of vigorous development. The main driving forces are the introduction and implementation of the concepts of One-Health, Internet of Things, and big data. Research hot topics include wearable and portable biosensing for point-of-care testing (POCT) and home care, noninvasive analysis, in vivo analysis, online analysis, field test, ultra-high temporal-spatial resolution, and single-cell biology. Technical challenges vary in different application scenarios, among which the thermal stability of biosensor recognition elements is a major concern, which is to be overcome by finding new solution. Literature statistics indicates that the Chinese researchers as a whole have made dramatic advances during the past two decades and now ranks top in terms of both paper number in total and the number of high impact papers. However, these do not mean that China is taking the lead in the field. Achieving academic excellence and exploring the global market will be the next goals for the Chinese researchers and industrial sector.