合成生物学的医学应用研究进展

崔金明; 王力为; 常志广; 臧中盛; 刘陈立

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投稿时间：2018-10-28

中文摘要: 在医学应用领域，合成生物学以人工设计的基因线路改造人体自身细胞，或改造细菌、病毒等人工生命体，再使其间接作用于人体。这些经人工设计的生命体能够感知疾病特异信号或人工信号、特异性靶向异常细胞和病灶区域、表达报告分子或释放治疗药物，从而实现对人体生理状态的监测，以及对肿瘤、代谢疾病、耐药菌感染等典型疾病的诊断与治疗。文章将综述了合成生物学的医学应用领域近期的一些研究进展。

中文关键词: 人工细胞人工细菌人工病毒人工噬菌体

Abstract:In the field of medical applications, synthetic biology researchers design genetic circuits to modify human cells, or to modify synthetic organisms such as bacteria and viruses and make them interact with the human body. These artificially designed organisms are capable of perceiving disease-specific signals or artificial signals, targeting abnormal cells and foci, expressing reporter molecules or releasing therapeutic drugs, thus enabling the monitoring of human physiological conditions and the diagnosis and treatment of typical diseases such as tumors, metabolic diseases, and drug-resistant bacteria infections. This article will comprehensively describe some recent research progress.

keywords: synthetic cell synthetic bacteria synthetic virus synthetic phage

文章编号： 中图分类号： 文献标志码：

基金项目:

作者	单位
崔金明	中国科学院深圳先进技术研究院深圳 518055
王力为	中国科学院前沿科学与教育局北京 100864
常志广	中国科学院深圳先进技术研究院深圳 518055
臧中盛	中国科学院深圳先进技术研究院深圳 518055
刘陈立	中国科学院深圳先进技术研究院深圳 518055

引用文本：
崔金明,王力为,常志广,臧中盛,刘陈立.合成生物学的医学应用研究进展[J].中国科学院院刊,2018,33(11):1218-1227.
CUI Jinming,WANG Liwei,CHANG Zhiguang,ZANG Zhongsheng,LIU Chenli.Progress of Synthetic Biology Research in Medical Applications[J].Bulletin of Chinese Academy of Sciences,2018,33(11):1218-1227.

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