Abstract:Life is an open information system that is self-replicating, adaptive, and self-organizing. The collection, processing, storage, integration, and analysis of biological information based on modern information technology (IT) propel life science research into the Fourth Paradigm of “Data-Intensive Scientific Discovery”, which definitely will make biotechnology (BT) toward a quantitative, computable, controllable, and predictable direction. Meanwhile, from the expression and regulation of genes to the information exchange and processing of neurons, information processing in organisms has infinitely inspired the development of information technology. From this perspective, the convergent development approach of BT and IT has its own essences in discipline connotation, laws of engineering development, demands of our time and society, and has brought about the ever-changing research paradigm, the ever-increasing innovation and breakthrough, and the increasingly extensive application scenarios. So in this way, it is of great significance to seize the commanding heights of both technology and industry competition.