Abstract:COVID-19 plague outbreak is accelerated due to the large amount of population movement just as at the time of Chinese traditional Spring Festival. As the heaviest plague region centered around Wuhan city, some measures such as urban-rural joint defence must be taken in whole Hubei province to guard against the even further deterioration. And in the level of whole China, such metropolis as Beijing, Shanghai, Guangzhou, Shenzhen and others which have very close contacts with Wuhan and big population flow after the Festival need to more precisely monitor population movement and identify potential infection areas and potential infected population to prevent to be sub-centers of plague outbreak by using modern big data technologies like mobile phone trajectories of the infected and potential infected people.