Abstract:Strengthening human resilience against disasters’ disturbance plays an important role in realizing the UN sustainable development goals. The study investigates the occurrence and evolution of major natural disasters and diseases in the world during the past century. It finds out that the major disasters gained frequency and impact after human entering the 21st century. Further, it indicates that the distorted human-nature relationship, rural decline and poverty in Sub-Sahara Africa, globalization have escalated the impact of major disasters. Finally, we propose ways to improve the resilient capacity of human being in terms of multiple perspectives.