Abstract:Environmental and health problems caused by chemical pollution, especially high-risk chemical pollution, have become an important factor affecting the public health. How to ensure that chemicals bring well-being to human society, while ensuring that they minimize their harm to the environment and human health, is a problem that needs to be solved urgently in the field of chemistry, especially environmental chemistry. This article summarizes the latest research progress in the risk identification, risk prevention, alternative research and development and evaluation of perfluorinated compounds and other substances, and systematically explores how to use green chemistry, combined with the risk management and control, to decrease the risk of the high-risk chemicals during their entire life cycle. The article also discusses the research progress, development direction, and future development of high-risk chemicals throughout the life cycle.