Abstract:The development of data science is valuable to clarify the theoretical boundary of data science, and provides new possibilities and opportunities for the sustainable development of computing intelligence. Meanwhile, the development of computing intelligence and the emergence of new intelligence paradigms can offer new chance for applications of big data in various industries and fields. This paper discusses the connotation of data science, the development of computing intelligence, the new intelligence paradigm, and lists the key applications leading the development of data science and computing intelligence. Furthermore, based on the discussion during the 667th Xiangshan Science Conference, seven key problems of data science and computing technology are proposed, anticipating to attract attentions of both researchers and applications in related fields, grasping the opportunity of the era, and promoting sustainable development of data science and computing intelligence.