Abstract:The complex environmental pollution in China greatly threatens the human health. Although the pollution control policies have taken a great effect in recent years, the resultant long-term, chronic health risks are still concerned. Until now, the causes of many regional high-incidence diseases are still unclear. In order to solve these environmental health problems, we need multi-disciplinary innovations in basic research to establish the comprehensive research chain of "pollution process-human exposure-body response-disease development". We need breakthroughs in interdisciplinary fields including exposomics, ultratrace measurement and source tracing methodology, molecular epidemiology, environmental big data, and artificial intelligence. Only in this way can we achieve the health risk-oriented precise prevention and control of environmental pollution.