Abstract:Strengthening basic research is one of the key strategies to achieve high-quality self-reliance of science and technology. On the occasion of the Centenary of the Communist Party of China, we review the development of science and technology in China and summarize the experience of promoting basic research to practical application. We also point out that the construction of innovation culture initiated by Chinese Academy of Sciences is useful to create a favorable environment for the basic research. Moreover, we describe the experience of how CAS Key Laboratory of Pathogenic Microbiology and Immunology promotes basic research to practical application.