Abstract:Since its establishment in 2004, the Broad Institute in the United States has been dedicated to combination research innovation with management innovation. In less than 10 years, it has been enlisted as one of the world-class life sciences research institutions and become the leader and signpost of cutting-edge innovation in life sciences. Its unique development model is worthy of reference. This study showed that the high-quality innovation and development of the Broad Institute is inseparable from:(1) its focus on the diagnosis and treatment needs of major diseases for scientific research; (2) the opening up of the channel from basic research to transformation and application; (3) the formation of an interdisciplinary and multi-level integrated research model; (4) its giving full play to the leading role of strategic scientists; (5) the gathering effect of small and excellent teams of outstanding scientists; (6) the implementation of highly flexible project organization and management; (7) the building of a first-class innovation network radiating the world. China can learn from its experience to promote the cutting-edge innovation of life sciences from following four aspects:(1) taking life sciences as the breakthrough in building China as a scientific and technological strength; (2) strengthening upper-level design for people's life and health; (3) laying a solid foundation of human resources of life sciences; (4) deeply integrating into the global innovation network of life sciences.