Abstract:The world is experiencing a great change with the combined impact of the COVID-19 pandemic. In the post-epidemic era, the world's major economies have begun to plan their strategic adjustments, economic revival and transformation. Industry 5.0, as the EU's new strategy to plan the "New Industrial Revolution" and promote industrial transformation in Europe, has raised wide attentions in the world and has become a hotspot of think tank research. Guided by the think tank double helix methodology, this study constructed a cognitive framework to study industrial strategy and its related complex system issues such as international relations, science and technology strategy, and economic and social development from systematic, subjective, scientific, global and practical perspectives, researched the feature, purpose and significance of Industry 5.0, as well as its impact, enlightenment and reference on the high-quality development of China's manufacturing, and put forward the coping strategies. This study fully revealed the value and significance of think tank double helix methodology in expanding the research horizon of such issues.