Abstract:The allocation of science and technology resources and the organization of science and technology forces, which has always been connected intrinsically with the nation’s development, has adopted different models, undertaken different missions, and played different roles in different stages of the development. This paper conducts a review and analysis on the major challenges faced by the nation, assignment of scientific tasks, organization of science and technology forces, and the output of scientific achievements, from the perspectives of “from standing upright to becoming prosperous and growing in strength”. It aims to provide a deep understanding of the nation’s focus on the state key laboratory reconstruction, as an important tool to facilitate the deepening of the science and technology system reform, and the exploration of the new nationwide system.