Abstract:In the report of the 20th National Congress of the Communist Party of China, it is emphasized that upholding the principles that science and technology constitute the primary productive force, talent is the primary resource, and innovation is the primary driving force is of utmost importance. The deep implementation of strategies such as the strategy for invigorating the country through science and education, the strategy for strengthening the nation through talent development, and the strategy for driving development through innovation is emphasized. Furthermore, the need to explore new domains and pathways for development, and continuously shape new dynamics and advantages for progress is underscored. Given the urgent needs of these development strategies, establish and develop "innovative research-oriented universities" that center on the integration of "education, science and technology, and human resources" has become a new break-through point for China's higher education to tackle the "bottlenecks" of scientific research and technology and to support major national strategic needs. Established in 2013, ShanghaiTech University, as an educational reform pilot entity, has made a series of explorations and innovations in promoting interdisciplinary research and integration of science and education in the past ten years, to serve China's national innovation-driven development strategy. This study, based on the practical experience of ShanghaiTech University over the past decade, explores how innovative research-oriented universities can promote scientific knowledge innovation, cultivate high-level talents, promote high-quality regional development, and help transform China's higher education.