Abstract:The generative large model GPT represented by ChatGPT is developing rapidly, which has aroused extensive discussion in academic circle and the industry and has an incalculable impact on foundational scientific research development. The study first sorts out the development of the GPT technological revolution, and discusses the new changes brought about by this technology in scientific research. Then, based on the three aspects of application status, core principles and innovation subjects, the impact of the GPT technological revolution on basic scientific research and its development suggestions for China are discussed. The study believes that GPT technology can certainly play a positive role in knowledge production, improve scientific research efficiency, and even promote scientific research paradigm changes, but it may also cause scientific research misconduct, weaken research credibility, and amplify the inherent bias of the Internet and other issues. Therefore, the study discusses how to develop Chinese foundational scientific research based on GPT technology. On the one hand, investing in the research and development of data and computing platforms that are independently controllable by the country and protected by intellectual property rights. On the other hand, emphasizing humancomputer collaboration and scientific research integrity supervision to create an open and transparent environment for Al development. In short, this study aims to provide policymakers and front-line researchers with an understanding perspective on the impact of GPT technology on fundamental science, promote the rational use of GPT technology, and provide a reference for the healthy development of the future academic ecology.