Abstract:The overall strategy of the “four major sectors”, the regional major strategies and the major functional oriented zoning strategy have strongly supported the regional coordinated development in China. However, it also brings the risk of exacerbating the imbalance and incoordination of regional development due to strategic differences and segmentation. Based on an analysis of the trends in regional coordinated development in China, this study puts forward the layout of China’s comprehensive function regions, which divides the mainland of China into 10 regions: the Beijing-Tianjin-Hebei region, the Yangtze River Delta region, the middle reaches of Yangtze River basin, the upper reaches of Yangtze River basin, the Southern coastal region, the lower reaches of Yellow River basin, the Ji shaped bay area of the Yellow River basin, the Northeast region, the arid region of Northwest China, and the Qinghai-Tibet Plateau, with the functional orientation and recent key tasks of different regions addressed. The layout of comprehensive function regions highlights the full coverage of territorial space, and the guidance of core area and major strategies. Moreover, it is conducive to promoting the convergence and integration of the overall strategy of the “four major sectors”, the regional major strategies, and the major functional oriented zoning strategy.