Abstract:Nowadays, China has expanded its partnerships with the participating countries in broader areas, with various cooperation platforms and projects being steadily implemented. These fruitful and productive collaborations have not only created tangible benefits for these countries, but have also contributed to promoting economic globalization, tackling global development challenges and improving global governance systems. The Guangdong-Hong Kong-Macao Greater Bay Area (GBA), as a crucial node of the Belt and Road Initiative (BRI), plays an important role in driving forward the BRI technological innovation agenda. This article explores the progresses of the GBA in BRI technological innovation practices, analyzes its advantages and challenges in this regard, and proposes pathways and measures for transforming the GBA into a leading hub of technological innovation under the BRI, for the purpose of advancing the leading role of the region in the initiative and contributing wisdom and power to technological innovation and cooperation worldwide.