Abstract:Since its establishment in 1949, Chinese Academy of Sciences (CAS) has attached great importance to the construction of institutional system and played an important role in the development of China’s scientific and technological system and national scientific research institutions. At the same time, there are also long-term problems in the academic organization system, the governance of research institutes, the legislation of scientific research institutions, etc. that need to be solved in the new era of deepening reform and system innovation. Taking the establishment of the CAS’s Charter and the Institute’s leadership system as the central clue, this study reviews the historical evolution of the institutional construction of CAS, and discusses its characteristics and related issues.