Abstract:With the promotion of soybean meal reduction and substitution as well as lower-protein diet technologies, China has become a leading global producer of feed amino acids. However, the amino acid industry faces significant challenges due to its relatively late start in independently developing industrial strains, resulting in relatively lagging key economic and technical parameters and a less robust intellectual property framework. The rapid progress of synthetic biology has provided promising avenues for the design and optimization of industrial amino acid-producing strains, offering new opportunities for the amino acid fermentation industry to enhance the global competitiveness. This study offers an in-depth analysis of the domestic and international market demand for feed amino acids, systematically reviews key technological breakthroughs in microbial amino acid production, and identifies the primary challenges confronting the domestic amino acid industry. Additionally, it further explores future development trends and challenges in microbial amino acid production, and proposes a series of targeted and comprehensive solutions to provide in-depth insights and guidance for the stable and accelerated growth of the microbial amino acid industry.