微球核心技术赋能生物制药全链条创新

吴颉; 周炜清; 赵岚; 马光辉*

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修订日期：2025-01-03

中文摘要: 生命科学和生物技术的发展推动着生物制药行业的飞速进步，用于疾病预防、诊断和治疗的生物医药制品不断涌现。微球作为一种重要的功能材料，以其灵活多变的粒径、形貌、结构、功能，在生物药物的发现、制备、分离、递送等多个环节均发挥重要作用。文章结合具体应用方向，综述了微球这一关键材料近年来的重要进展及其在细胞培养、层析分离、药物递送、疫苗佐剂等领域的应用，并对其今后的发展方向提出了建议。

中文关键词: 生物制药微球细胞培养生物分离递送载体

Abstract:Advancements in life science and biotechnology have boosted the evolution of the biopharmaceutical industry with the continual emergence of biomedical products for disease prevention, diagnosis, and treatment. Microspheres, as crucial functional materials, play a significant role in the discovery, preparation, separation, and delivery of biological drugs due to their flexible size, morphology, structure, and function. This study reviews recent significant advancements in microspheres and their applications in cell culture, chromatographic separation, drug delivery, and as vaccine adjuvants. Additionally, it proposes future trends for the development of microspheres.

keywords: biopharmaceutical microspheres cell culture bioseparation delivery vector

文章编号： 中图分类号： 文献标志码：

基金项目:国家自然科学基金重点项目（U23A20532）;国家重点研发计划项目（2021YFC2103400;2020YFA0112603）;中国科学院C类战略性先导科技专项（XDC0250101）

作者	单位
吴颉	中国科学院过程工程研究所生物药制备与递送全国重点实验室北京 100190 中国科学院大学化学工程学院北京 100049
周炜清	中国科学院过程工程研究所生物药制备与递送全国重点实验室北京 100190 中国科学院大学化学工程学院北京 100049
赵岚	中国科学院过程工程研究所生物药制备与递送全国重点实验室北京 100190 中国科学院大学化学工程学院北京 100049
马光辉*	中国科学院过程工程研究所生物药制备与递送全国重点实验室北京 100190 中国科学院大学化学工程学院北京 100049

Author Name	Affiliation
WU Jie	State Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China
ZHOU Weiqing	State Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China
ZHAO Lan	State Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China
MA Guanghui*	State Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China

引用文本：
吴颉,周炜清,赵岚,马光辉*.微球核心技术赋能生物制药全链条创新[J].中国科学院院刊,2025,40(1):79-90.
WU Jie,ZHOU Weiqing,ZHAO Lan,MA Guanghui*.Microsphere core technology boosts innovation of biopharmaceutical industry chain[J].Bulletin of Chinese Academy of Sciences,2025,40(1):79-90.