Abstract:In the era of rapid development of synthetic biology, biomanufacturing, as a bridge between life sciences and engineering technologies, is gradually demonstrating its extraordinary potential to reshape industrial landscapes. However, challenges such as production efficiency, cost control, and process monitoring still hinder the smooth transition from laboratory innovations to industrialscale implementation. Intelligent biomanufacturing has emerged as a new form of productive force, offering innovative solutions to these problems. This study reviews the latest advances in bioprocess engineering and intelligent biomanufacturing, focusing on three key technological systems: intelligent sensing, intelligent analysis, and intelligent control. Intelligent sensing technology acts as the “eyes” of biological processes, enabling real-time, high-precision environmental monitoring. Intelligent analysis, as the “brain”, uncovers underlying patterns in data, providing decision-making insights. Intelligent control, the “commander”, precisely regulates bioprocesses to ensure efficient and stable operation. The integration of these three technologies significantly enhances the intelligence of biomanufacturing, providing powerful momentum to overcome industrialization bottlenecks. Looking ahead, intelligent biomanufacturing will continue to evolve through ongoing technological innovation and interdisciplinary collaboration, expanding its applications toward greater efficiency, intelligence, and sustainability, contributing to the progress and prosperity of human society.