Abstract:This study analyzes the correlation between the strategic layouts of international science and technology cooperation (ISTC) of China and the international situations during period from the 10th Five-Year Plan to 13th Five-Year Plan. Furthermore, from the perspectives of ISTC requirements, development principles and objectives, the work comparatively studies on the deployment of science technology and innovation policies to ISTC at different stages, as well as the key contents of ISTC proposed at different periods. On this basis, the evolution path and characteristics of ISTC are elaborated accordingly. Finally, in the light of the current international statuses, opportunities, and challenges that China is facing, the recommendations are put forward on the formulation of the ISTC policy in the next stage.