Abstract:The scientific governance is the most important to S&T because of its dual nature for societies. The concept and method of governance has been adapted to strengthen the management of the S&T systematically, which is the scientific choice of national economic and social development. As the one of the significant breakthroughs to innovation, disruptive technology is the strategic opportunity to build China into a world science and technology power. With the potential, dramatic, and systematic impact, disruptive technology could reshape the rules and structures. For disruptive technological innovation, it is urgent to introduce the forward-looking governance notion to master its great impact in advance, and promote its development and application actively and scientifically. In order to promote the disruptive technology development and predict and reduce its risks, this study constructs a forward-looking governance system of disruptive technology innovation, discusses the basic characteristics of the system, establishes the core research framework, and provides the suggestions on the main governance process.