Abstract:Regional integration is entering a new stage, and the connotation, focus, and role have undergone important changes. This article discusses the new trends of regional integration and the medium and long-term strategies of China on the basis of analyzing the causes of repeated twists and turns in international regional integration. It is proposed that the change of the integration center and the unreasonable cost-benefit allocation mechanism have led to the ups and downs of international regional integration led by developed countries. The basic contradiction between socialized large-scale production and private ownership of means of production determines the integration cost-benefit allocation problem; the international regional integration led by developed countries will continue to encounter setbacks. Public ownership of the means of production has laid the institutional foundation for solving the problem of costbenefit allocation; international regional integration with imports as the important feature of developing countries is conducive to reduce the cost of integration and integrate the interests of capital owners and laborers, so that the international regional integration promoted by the developing countries is expected to become a new model of sustainable integration. International and domestic integration that promotes each other will help the acceleration of this process. China should seize the opportunity and take the initiative to act, and optimize the regional pattern, reshape regional relations, enhance the overall competitiveness, build the key domestic integration areas into a complex of China's major productive forces, and integrate China-led international integration regionalization growth pole for China's further development in the world.