Abstract:Recently, wildlife infectious diseases have become a more and more serious problem in the world which imposes a big threat to bio-safety and eco-safety of worldwide. Accelerated climate change and human activities are key driving forces in causing more frequent occurrences of wildlife infectious diseases. Climate change could create favorable conditions for large-scale outbreak or invasion of wildlife infectious diseases by altering range shift or habitat of wildlife infectious diseases or their host/vectors. Human disturbance increases interspecific transmission of pathogens across people, wild and domestic animals, as well as their spread velocity facilitated by the modern transportation systems, and then occurrence of zoonotic diseases. In order to deal with the great challenge of more serious wildlife infectious diseases, it is necessary to strengthen the national monitoring and prevention system of wildlife infectious diseases in China, to promote the capacity for research, monitoring and forecasting, intervention and control on wildlife infectious diseases, so as to serve the bio-safety and eco-safety strategy of China.