Abstract:Major countries have launched brain initiatives for competition, aiming to gain strategic priority in the area of brain ultimate frontier for human being in the course of recognizing nature. The US BRAIN Initiative is a scientific project comparable to the Human Genome Project in scale and potential impact. Accelerating the development and application of new technologies and tools is the driving force for the US BRAIN Initiative, which takes the lead in race owing to its realistic and innovative development mode. This study briefly reviews the implementation progress, the strategic reports and research achievements of the US BRAIN Initiative, and summarizes the main characteristics of its implementation. Finally, this study puts forward six advisory opinions:(1) strengthening the top-level design, (2) energetically developing originally created biotechnology, (3) setting up studies for data governance in advance, (4) exploring the mode for government and enterprise cooperation, (5) establishing interdisciplinary network for group research, (6) practicing responsible study, in hope of inspiring more good ideas for the development of brain science in China.