Abstract:Due to the new round of sci-tech revolution and industrial transformation, the relation between scientific progress and national security has been upgraded to an unprecedented strategic height. Therefore, it is vitally important to explore the current situation and future trajectory of the relation between the two. This study discusses the new trends between global scientific progress and the security of sovereign countries. It believes that scientific progress has catalyzed the new geopolitical contests, development contradiction and hegemonic tools in global security governance, thereby enlightening China's approach to national security. To maintain holistic national security, China should formulate an overall strategic program to coordinate scientific progress and national security and also fortify a sound protection system. Moreover, to promote global common security, China should explore a scientific practice route, demonstrate China's insight and responsibility, and endeavor to build a community of a shared future for mankind with universal security in the global scientific trend.