Abstract:The strategic significance of top-down design theory, method and technical system of high-end CNC machine tools is expounded, so as to realize the independent research and development of high-end CNC machine tools, satisfy the requirements of high-end users in key fields and maintain the independence and control of the core technologies. The top-down design methods and some key scientific problems are proposed, including static-dynamic stiffness design, geometric accuracy design, thermal balance design, and assembly process accuracy design, based on the spatial position and attitude error, relative dynamic flexibility of the working space, through the design, processing and assembly process. The research progress of the international leading research institutions in the field of top-down design of machine tools is discussed. Finally, some policy suggestions on developing and improving top-down design technology of high-end CNC machine tools in China are put forward.