| 目次 |
| 专题：生物制造——回顾与展望 |
| “专题：生物制造——回顾与展望”编者按 ------------------------------------------------------------------------------------------------------------------------------------------1 |
| 我国生物制造底盘菌种现状、问题及对策 陈国强 吴赴清 郑 爽 丁 军 盛君婷 ------------------------------------------------------------------------------------------------------------------------------------------2 |
| 新型基因编辑底盘工具的开发现状与展望 刘子贤 李承平 刘俊杰 ------------------------------------------------------------------------------------------------------------------------------------------14 |
| 微生物制造饲用氨基酸助力豆粕减量替代 刘 佳 盛 琦 刘开放 刘立明 ------------------------------------------------------------------------------------------------------------------------------------------25 |
| 工业丝状真菌生物制造的现状和展望 杜志强 门 萍 周 宇 张 璇 黄雪年 吕雪峰 ------------------------------------------------------------------------------------------------------------------------------------------36 |
| 萜类化合物高效发现与产业化制造 池豪铭 鄂丽影 刘天罡 ------------------------------------------------------------------------------------------------------------------------------------------47 |
| 细胞工厂设计数字化赋能绿色生物制造 孟繁泽 曹 锐 胡 冰 秦 磊 李 春 ------------------------------------------------------------------------------------------------------------------------------------------67 |
| 微球核心技术赋能生物制药全链条创新 吴 颉 周炜清 赵 岚 马光辉 ------------------------------------------------------------------------------------------------------------------------------------------79 |
| 基于微流控技术的工程细胞高通量表型测试技术与装备研究进展 李 爽 郭肖杰 陈海博 陈思思 笪 鑫 李峥辉 刘芹秀 王 怡 邢新会 张 翀 ------------------------------------------------------------------------------------------------------------------------------------------91 |
| 生物过程工程与智能生物制造 王 冠 庄英萍 ------------------------------------------------------------------------------------------------------------------------------------------107 |
| 全球生物制造产业关键平台设施建设现状分析与思考 吴晓燕 陈 方 单耀莹 陆安静 ------------------------------------------------------------------------------------------------------------------------------------------116 |
| 我国合成生物产业创新发展路径与政策保障研究 耿红军 王 昶 ------------------------------------------------------------------------------------------------------------------------------------------127 |
| 战略与决策研究 |
| 2025年中国经济增长速度预测分析与政策建议 陈锡康 杨翠红 祝坤福 王会娟 李鑫茹 赵 宇 ------------------------------------------------------------------------------------------------------------------------------------------140 |
| 人工智能驱动信息技术体系重构与再造——兼评《中国至2050年信息科技发展路线图》 洪学海 ------------------------------------------------------------------------------------------------------------------------------------------149 |
| 政策与管理研究 |
| 西藏生态文明高地建设科学路径 王小丹 张建新 魏 达 赵 慧 洪江涛 梁钰凌 祁亚辉 袁正蓉 ------------------------------------------------------------------------------------------------------------------------------------------162 |
| 大数据支撑现代农业产业高质量发展的内在逻辑与政策建议 李颖明 王子彤 汪明月 刘释疑 ------------------------------------------------------------------------------------------------------------------------------------------172 |
| 加强我国新污染物的环境控制技术与管理政策研究 马 莹 李 想 骆永明 ------------------------------------------------------------------------------------------------------------------------------------------181 |
| 北极矿产资源开发利用及中国应对 苏轶娜 ------------------------------------------------------------------------------------------------------------------------------------------193 |
| 科技与社会 |
| 循环海洋生物产业重新设计和从头设计 张 卫 张树峰 周涵韬 戴民汉 ------------------------------------------------------------------------------------------------------------------------------------------204 |
| 美国民间生物安全智库发展现状及特点分析 马文兵 宋 蔷 王 磊 ------------------------------------------------------------------------------------------------------------------------------------------216 |
| 资讯与观察 |
| 政策速览（2024年12月） ------------------------------------------------------------------------------------------------------------------------------------------229 |
| 快讯 |
| 《中国科学院院刊》“2023年度优秀论文” ------------------------------------------------------------------------------------------------------------------------------------------232 |
| 《中国科学院院刊》入选2023年和2024年F5000论文名单 ------------------------------------------------------------------------------------------------------------------------------------------233 |
| 锐意进取，行稳致远——《中国科学院院刊》 2024 年印记 ------------------------------------------------------------------------------------------------------------------------------------------235 |
| 生物制造构想图 --------------------------------------------------------------------------------------------------------------------------------------------------封面 |
| 中国科学院党组、中国科学院学部主席团2025新年贺词 --------------------------------------------------------------------------------------------------------------------------------------------------封二 |
| 《中国科学院院刊》新媒体 --------------------------------------------------------------------------------------------------------------------------------------------------封三 |
| 欢迎订阅《中国科学院院刊》 --------------------------------------------------------------------------------------------------------------------------------------------------封四 |
| CONTENTS |
| Biomanufacturing: Retrospect and Prospects |
| Editorial for Special Column “Biomanufacturing: Retrospect and Prospects” ------------------------------------------------------------------------------------------------------------------------------------------1 |
| Current status and applications of microbial chassis strains for Chinese biomanufacturing industry CHEN Guo-Qiang et al. ------------------------------------------------------------------------------------------------------------------------------------------2 |
| Recent progress and perspectives on development of gene editing tools LIU Zi-Xian et al. ------------------------------------------------------------------------------------------------------------------------------------------14 |
| Microbial production of feed amino acids promotes reduction and replacement of soybean meal LIU Jia et al. ------------------------------------------------------------------------------------------------------------------------------------------25 |
| Current status and prospect of industrial filamentous fungi in biomanufacturing DU Zhiqiang et al. ------------------------------------------------------------------------------------------------------------------------------------------36 |
| Efficient discovery and industrialized manufacture of terpenoids CHI Haoming et al. ------------------------------------------------------------------------------------------------------------------------------------------47 |
| Digitalized design of cell factory enables green biomanufacturing MENG Fanze et al. ------------------------------------------------------------------------------------------------------------------------------------------67 |
| Microsphere core technology boosts innovation of biopharmaceutical industry chain WU Jie et al. ------------------------------------------------------------------------------------------------------------------------------------------79 |
| Research progress in high-throughput phenotype testing technology and equipment for engineering cells based on microfluidics LI Shuang et al. ------------------------------------------------------------------------------------------------------------------------------------------91 |
| Bioprocess engineering and intelligent biomanufacturing WANG Guan et al. ------------------------------------------------------------------------------------------------------------------------------------------107 |
| Analysis and reflections on key platform facilities construction of global biomanufacturing industry WU Xiaoyan et al. ------------------------------------------------------------------------------------------------------------------------------------------116 |
| Research on innovative development path and policy guarantee of China’s synthetic biology industry GENG Hongjun et al. ------------------------------------------------------------------------------------------------------------------------------------------127 |
| Strategy & Policy Decision Research |
| Forecast of China’s economic growth rate in 2025 and policy suggestions CHEN Xikang et al. ------------------------------------------------------------------------------------------------------------------------------------------140 |
| Artificial intelligence driven information technology system restructuring and reconstruction—Review of Information Science & Technology in China: A Roadmap to 2050 HONG Xuehai ------------------------------------------------------------------------------------------------------------------------------------------149 |
| Policy & Management Research |
| Scientific approach to building a highland of ecological civilization in Xizang of China WANG Xiaodan et al. ------------------------------------------------------------------------------------------------------------------------------------------162 |
| Internal logic and policy recommendations of big data to support high-quality development of modern agricultural industry LI Yingming et al. ------------------------------------------------------------------------------------------------------------------------------------------172 |
| Strengthen research on environmental control technologies and management policies for emerging contaminants in China MA Ying et al. ------------------------------------------------------------------------------------------------------------------------------------------181 |
| Development and utilization of mineral resources in the Arctic and China’s strategic countermeasures SU Yina ------------------------------------------------------------------------------------------------------------------------------------------193 |
| S&T and Society |
| Redesign and de novo design of circular blue bioindustry ZHANG Wei et al. ------------------------------------------------------------------------------------------------------------------------------------------204 |
| Analysis on development status and characteristics of non-governmental bio-safety and bio-security think tanks in the United States MA Wenbing et al. ------------------------------------------------------------------------------------------------------------------------------------------216 |
| Information & Observation |
| Policy Overview (December, 2024) ------------------------------------------------------------------------------------------------------------------------------------------229 |